© Copyright 2026 American Medical Association. All rights reserved.
High dose rate (HDR) electronic brachytherapy is a specialized form of radiation therapy that utilizes an X-ray tube to deliver electronically generated photons as the radiation source. This innovative approach eliminates the need for traditional radioactive isotopes, making the procedure safer and more efficient. HDR electronic brachytherapy is primarily indicated for the treatment of breast cancer, particularly following a lumpectomy, where the goal is to target and destroy any remaining cancerous cells in the breast tissue. The procedure involves the insertion of a brachytherapy applicator device into the body, either interstitially (within the tissue) or intracavitarily (within a body cavity), at the site of the malignant neoplasm or the tumor bed. This precise placement is crucial for ensuring that the radiation is delivered accurately to the intended area. Before treatment, the radiation oncologist assesses the target volume and determines the prescribed dose of radiation. This process may involve adjustments to the treatment plan, which are facilitated by computerized brachytherapy dosimetry. Once the treatment parameters are established, the X-ray generator is connected to the applicator device, and appropriate shielding is applied to protect surrounding healthy tissues from radiation exposure. The control panel is then set to deliver the prescribed dose, and a preliminary check run of the X-ray generator is conducted to ensure proper functioning. The actual delivery of high-dose electronic brachytherapy occurs over a specified duration, typically ranging from 10 to 40 minutes, depending on the treatment plan. If a multichannel applicator is utilized, the procedure may be repeated as necessary to ensure comprehensive treatment. Each treatment session is divided into fractions, with a standard regimen following lumpectomy consisting of 10 fractions delivered over five days, with two fractions administered per day. The brachytherapy applicator remains in place throughout the entire course of treatment, allowing for continuous and targeted radiation delivery.
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