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Autologous adipose-derived regenerative cell (ADRC) therapy is a medical procedure designed to address partial thickness rotator cuff tears by utilizing the patient's own adipose (fat) tissue. This innovative approach aims to promote healing of the tendons surrounding the shoulder joint, which are critical for shoulder function. Traditional conservative treatments, such as physical therapy or steroid injections, may alleviate symptoms but do not effectively restore the integrity of a torn rotator cuff. Surgical interventions can be successful; however, they carry a significant risk of re-rupture. One contributing factor to the rotator cuff's poor healing response is the inadequate supply of stem cells at the tendon-bone interface, which are essential for the development of connective tissue, lymphatic tissue, and blood vessels. The ADRC therapy procedure involves several key steps: first, the harvesting of adipose tissue, typically performed through liposuction under local anesthesia from areas such as the trunk or thigh. Following harvesting, the adipose tissue is cleaned, filtered, and processed to isolate the regenerative cells. This processing includes incubation with an enzymatic reagent to facilitate cell isolation and dissociation, followed by multiple steps of filtration, washing, and centrifugation. Once prepared, the autologous stem cell product is injected into the supraspinatus tendon and its surrounding area, guided by ultrasound to ensure precision. The injection site is then dressed to promote healing. Although the procedure is still under investigation in clinical trials, preliminary results indicate promising outcomes in repairing partially torn rotator cuffs, with a low incidence of side effects and re-tears.
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