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Official Description

Subretinal injection of a pharmacologic agent, including vitrectomy and 1 or more retinotomies

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 0810T refers to a specialized procedure known as a subretinal injection of a pharmacologic agent, which is performed in conjunction with vitrectomy and one or more retinotomies. This procedure is primarily utilized to deliver therapeutic pharmaceutical drugs directly into the subretinal space, which is the area located between the photoreceptors and the retinal pigment epithelium (RPE) layer of the eye. The subretinal injection is particularly significant in the treatment of various vitreoretinal diseases. It is commonly employed for administering gene therapy aimed at inherited retinal diseases, as well as for delivering tissue plasminogen activator (tPA) to address submacular hemorrhage. Additionally, the procedure may involve the injection of bevacizumab to manage large macular bleeding and the use of fluid injections to alleviate macular folds. During the procedure, the sclera, which is the white outer coating of the eyeball, is accessed through a conjunctival periotomy, allowing for the insertion of a trocar into the globe of the eye. This is followed by the placement of an infusion cannula to maintain intraocular pressure. The procedure typically involves the insertion of two additional trocars to facilitate a three-port vitrectomy, during which saline solution is injected to stabilize the intraocular environment. Any retinal tears identified during the procedure are repaired to prevent further complications. The pharmacologic agent intended for injection is prepared in a microdosing syringe, and a subretinal cannula is carefully inserted under magnification, advancing it through a small retinotomy to reach the subretinal space. The injection is then made into a viable retinal area, and the vitreous cavity is rinsed to ensure proper distribution of the medication. Air-fluid exchange may also be performed to promote the formation of subretinal blebs in the posterior pole, with thorough documentation conducted prior to the removal of the trocars. Finally, the conjunctiva is massaged over the openings, and the sclerotomies are closed. Post-procedure care includes the administration of subconjunctival corticosteroids and antibiotics, followed by the application of a wound dressing and an eye patch to support recovery.

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