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A fine needle aspiration (FNA) biopsy is a minimally invasive procedure designed to collect samples of fluid or cells from a lesion, such as a cyst or a solid mass. This procedure is particularly useful when traditional open biopsy methods pose risks, such as disrupting surgical planes or causing tumor seeding, especially in cases involving previously treated or irradiated lesions. The use of imaging guidance, specifically Magnetic Resonance Imaging (MRI) or Computed Tomography (CT), enhances the precision of the biopsy by allowing healthcare professionals to target lesions that are difficult to locate or access through standard techniques. This includes lesions situated in challenging anatomical locations, such as the abdomen, thorax, or deep-seated nodules in the neck, as well as masses within vital organs like the lungs, pancreas, liver, or kidneys. During the procedure, a radiopaque marker may be placed over the lesion to facilitate accurate imaging. The patient is then scanned in small increments to identify the optimal site for the biopsy. In some instances, intravenous (IV) sedation may be administered to ensure patient comfort. The biopsy site is prepared using local anesthesia and antiseptic solutions to minimize the risk of infection. A coaxial biopsy guide needle is inserted, followed by a second imaging scan to confirm the needle's correct placement. Subsequently, a biopsy gun is attached to the guide needle, which is activated to penetrate the mass and aspirate the necessary sample cells or fluid. This process may be repeated multiple times to obtain sufficient material for analysis. The collected specimens are then prepared by smearing them onto microscope slides, air-drying, fixing, and staining them for microscopic examination. This immediate analysis helps determine whether the samples are adequate or if additional biopsies are required.
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