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Code deleted, see 11102, 11104, 11106

Official Description

Biopsy of skin, subcutaneous tissue and/or mucous membrane (including simple closure), unless otherwise listed; single lesion

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 11100 refers to the procedure of performing a biopsy on skin, subcutaneous tissue, and/or mucous membrane, specifically for a single lesion. This procedure involves the physician carefully removing a sample of tissue from the identified lesion for further examination. The process begins with the cleansing of the lesion site to minimize the risk of infection, followed by the administration of a local anesthetic to ensure patient comfort during the procedure. A scalpel is then utilized to excise either a portion or the entirety of the lesion, depending on the clinical requirements. Once the tissue sample is obtained, it is sent to a laboratory for histologic examination, which is a separate reportable service. After the biopsy is completed, the physician may close the biopsy site using sutures in a single layer or may opt to leave it open to allow for natural granulation. It is important to note that this code is specifically designated for a single lesion, while additional lesions would require the use of CPT® Code 11101 for each separate biopsy performed.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure coded as CPT® 11100 is indicated for the biopsy of a single lesion located on the skin, subcutaneous tissue, or mucous membrane. The specific indications for performing this biopsy may include:

  • Suspicious Lesion: A lesion that exhibits characteristics suggestive of malignancy or other pathological conditions that require histological evaluation.
  • Diagnostic Purposes: To obtain tissue for diagnosis when a lesion presents with atypical features or when there is uncertainty regarding its nature.
  • Monitoring Changes: For lesions that have changed in size, shape, or color, necessitating further investigation to rule out any serious conditions.

2. Procedure

The procedure for CPT® 11100 involves several key steps that ensure the effective and safe collection of a tissue sample from the lesion. The steps are as follows:

  • Step 1: Preparation of the Site The physician begins by thoroughly cleansing the area surrounding the lesion to eliminate any potential contaminants. This step is crucial for reducing the risk of infection during the biopsy.
  • Step 2: Anesthesia Administration Following the cleansing, a local anesthetic is injected into the area around the lesion. This is done to ensure that the patient remains comfortable and pain-free throughout the procedure.
  • Step 3: Tissue Removal Using a scalpel, the physician carefully excises the lesion, which may involve removing either a portion or the entire lesion depending on the clinical judgment and the characteristics of the lesion. The excised tissue is then collected for further analysis.
  • Step 4: Sample Handling After the tissue has been removed, it is placed in a suitable container and sent to a laboratory for histologic examination. This examination is essential for diagnosing any underlying conditions related to the lesion.
  • Step 5: Closure of the Biopsy Site Finally, the physician may choose to close the biopsy site with sutures in a single layer, ensuring proper healing, or may leave it open to granulate naturally, depending on the specific circumstances of the procedure.

3. Post-Procedure

After the biopsy procedure coded as CPT® 11100, the patient may be advised on specific post-procedure care to promote healing and minimize complications. This may include instructions on keeping the biopsy site clean and dry, monitoring for signs of infection such as increased redness, swelling, or discharge, and managing any discomfort with over-the-counter pain relief as needed. The physician may also schedule a follow-up appointment to discuss the results of the histologic examination and any further treatment options if necessary. It is important for patients to adhere to the post-procedure guidelines provided by their healthcare provider to ensure optimal recovery.

Short Descr BIOPSY SKIN LESION
Medium Descr BX SKIN SUBCUTANEOUS&/MUCOUS MEMBRANE 1 LESION
Long Descr Biopsy of skin, subcutaneous tissue and/or mucous membrane (including simple closure), unless otherwise listed; single lesion
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6A - Minor procedures - skin
MUE Not applicable/unspecified.
CCS Clinical Classification 173 - Other diagnostic procedures on skin and subcutaneous tissue
Date
Action
Notes
2019-01-01 Deleted Code deleted, see 11102, 11104, 11106
2011-01-01 Changed Short description changed.
2004-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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Description
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