© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 11100 refers to the procedure of performing a biopsy on skin, subcutaneous tissue, and/or mucous membrane, specifically for a single lesion. This procedure involves the physician carefully removing a sample of tissue from the identified lesion for further examination. The process begins with the cleansing of the lesion site to minimize the risk of infection, followed by the administration of a local anesthetic to ensure patient comfort during the procedure. A scalpel is then utilized to excise either a portion or the entirety of the lesion, depending on the clinical requirements. Once the tissue sample is obtained, it is sent to a laboratory for histologic examination, which is a separate reportable service. After the biopsy is completed, the physician may close the biopsy site using sutures in a single layer or may opt to leave it open to allow for natural granulation. It is important to note that this code is specifically designated for a single lesion, while additional lesions would require the use of CPT® Code 11101 for each separate biopsy performed.
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