© Copyright 2026 American Medical Association. All rights reserved.
Intralesional injection is a medical procedure that involves the administration of a pharmacologic agent directly into a lesion or multiple lesions on the skin. This technique is particularly effective for delivering medications, such as corticosteroids, directly to the site of inflammation or abnormal tissue growth. Corticosteroids are the most commonly utilized drugs in this procedure, as they are known for their anti-inflammatory properties and ability to treat various skin disorders, including acute or chronic inflammatory processes, hyperplastic conditions, and hypertrophic skin disorders. During the procedure, a syringe filled with the chosen pharmacologic agent is equipped with a fine needle, which is then carefully inserted beneath the skin at the targeted lesion site. Once in position, the medication is injected, allowing it to disperse slowly through the dermis. This method provides prolonged localized therapy, ensuring that the medication remains effective at the site of injection for an extended period. For coding purposes, CPT® Code 11900 is used for the injection of up to and including seven lesions, while CPT® Code 11901 is designated for cases involving more than seven lesions.
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