© Copyright 2026 American Medical Association. All rights reserved.
An acellular dermal allograft is a specialized medical procedure that involves the use of a skin graft derived from a cadaver donor. This graft is unique in that it has undergone a chemical treatment process to remove the epidermal cellular components, which are the cells that can trigger immune responses in the recipient. By eliminating these antigenic components, the likelihood of the graft being rejected by the body is significantly reduced. This procedure is particularly beneficial for covering skin defects or filling soft tissue defects in various anatomical areas, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. Originally developed for treating burn victims, the application of acellular dermal allografts has expanded to include reconstructive surgery, dental and oral procedures, as well as plastic and cosmetic surgeries. The process involves rehydrating the graft sheets in an isotonic sodium chloride solution, trimming them to fit the wound, and applying them in layers to the prepared wound bed, which is then secured with absorbable sutures. This method not only aids in the healing process but also enhances the aesthetic outcome of the surgical site.
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