© Copyright 2026 American Medical Association. All rights reserved.
A dermal xenograft, specifically identified by CPT® Code 15400, is a medical procedure involving the application of skin tissue obtained from a different species, commonly porcine (pig), to facilitate temporary wound closure. This procedure is typically performed on the trunk, arms, or legs of patients. The xenograft serves as a biological dressing, providing a protective layer over the wound until it is eventually rejected by the patient's immune system. The skin graft is processed through methods such as glycerol treatment and either freezing with liquid nitrogen or freeze-drying, also known as lyophilization, to preserve its viability. When ready for application, the xenograft is either thawed or rehydrated, depending on its preservation method, and is then carefully placed onto a prepared wound bed. The graft is secured in position using sutures to ensure it remains in place during the healing process. This code is applicable for the first 100 square centimeters of skin grafting in adults or for 1% of the total body surface area (TBSA) in infants and children. For any additional coverage beyond these parameters, CPT® Code 15401 should be utilized.
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