© Copyright 2026 American Medical Association. All rights reserved.
A dermal xenograft is a specialized medical procedure involving the application of skin tissue obtained from another species, typically porcine (pig), to facilitate temporary wound closure. This procedure is particularly relevant for areas of the body that require careful attention, such as the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. The xenograft serves as a biological dressing, providing a protective layer over the wound while promoting healing until it is eventually rejected by the patient's immune system. The skin graft is processed through methods such as glycerol treatment and freezing with liquid nitrogen or lyophilization (freeze-drying), which preserves the tissue for later use. When the graft is needed, it is either thawed or rehydrated before being meticulously applied to the prepared wound bed and secured in place, often with sutures. This procedure is coded under CPT® Code 15421, which is specifically designated for each additional 100 square centimeters of xenograft applied beyond the initial 100 square centimeters or 1% of total body surface area (TBSA) in infants and children. It is important to note that this code is used in conjunction with CPT® Code 15420, which covers the first 100 square centimeters or less in adults or the first 1% of TBSA in infants and children.
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