© Copyright 2026 American Medical Association. All rights reserved.
A percutaneous needle core biopsy of the breast is a minimally invasive procedure used to obtain tissue samples from a breast lesion. This procedure is performed without the use of imaging guidance, which means that the physician relies on physical examination and palpation to locate the area of concern. The process begins with the cleansing of the skin over the biopsy site, followed by the administration of a local anesthetic to minimize discomfort for the patient. Once the area is prepared, the physician palpates the lump to accurately identify its location. With one hand stabilizing the lesion, the physician uses the other hand to insert a hollow needle into the lesion. To ensure that a sufficient amount of tissue is collected for diagnostic purposes, multiple core needle insertions—typically between three to six—are performed. After the necessary tissue samples are obtained, they are sent to a laboratory for pathological examination, where they will be analyzed for any abnormalities or signs of disease.
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