© Copyright 2026 American Medical Association. All rights reserved.
An open bone biopsy is a surgical procedure that involves the removal of a small sample of bone tissue for pathological examination. This procedure is typically performed under either regional block or general anesthesia to ensure the patient's comfort. The primary purpose of a bone biopsy is to investigate various conditions related to bone health, including persistent bone pain or tenderness, and to confirm diagnoses that may have been suggested by other diagnostic tests. It is particularly useful in differentiating between benign bone masses and malignant conditions such as bone cancer. Additionally, bone biopsies can aid in diagnosing bone diseases or infections, including osteoporosis, osteomalacia, and osteomyelitis. During the procedure, a skin incision is made directly over the area of interest, and the incision is extended through the subcutaneous tissue and muscle until the bone is reached. A small segment of bone is then excised and sent to a laboratory for further analysis. To manage bleeding during the procedure, any blood vessels encountered are either tied off or cauterized. After the biopsy is completed, the surgical site is thoroughly cleansed, and the incision is sutured closed and bandaged to promote healing.
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