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Official Description

Biopsy, soft tissue of thigh or knee area; superficial

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 27323 refers to a biopsy procedure performed on the soft tissues of the thigh or knee area, specifically targeting superficial structures. Soft tissues encompass a variety of components, including muscles, tendons, fat, blood vessels, lymph vessels, nerves, and the tissues that surround joints. During this procedure, anesthesia is administered, which may be local, regional, or general, or conscious sedation, depending on the specific site and depth of the biopsy being performed. The process begins with the cleansing of the skin over the biopsy site to minimize the risk of infection. Following this, a precise incision is made, and the tissue is carefully dissected down to the mass or lesion, ensuring that surrounding blood vessels and nerves are protected throughout the procedure. A sample of the tissue is then obtained and sent to a laboratory for histological evaluation, which is reported separately. After the tissue sample is collected, the incision is closed using sutures. It is important to note that for a superficial biopsy, the appropriate code to use is 27323, while for biopsies that involve deeper tissues requiring more extensive dissection, such as those below the muscle fascia (subfascial) or within the muscle itself (intramuscular), the code 27324 should be utilized.

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