© Copyright 2026 American Medical Association. All rights reserved.
Percutaneous core needle biopsy of the lung or mediastinum is a diagnostic procedure utilized to obtain tissue samples from masses or lesions located in these areas. This method is particularly valuable for the initial assessment of suspicious growths, allowing for histologic examination to determine the nature of the tissue. The procedure involves the use of a specially designed needle that extracts a core sample of tissue, which is then analyzed in a laboratory setting. Imaging guidance, such as fluoroscopy, computed tomography (CT), ultrasound, or magnetic resonance imaging (MRI), is employed to accurately locate the lesion and guide the needle to the appropriate site. During the procedure, the patient is positioned in a manner that facilitates access to the lesion, which may involve lying supine, prone, or in an oblique position. Prior to the biopsy, the skin over the biopsy site is cleansed and anesthetized to minimize discomfort. The needle is carefully inserted at the margin of the lesion, and its position is confirmed to ensure accurate sampling. A small incision may be made to facilitate the needle's passage through the skin. The cutting needle system is then activated to obtain the tissue core, and multiple passes may be required to secure an adequate sample for analysis. Following the biopsy, the patient is monitored for any complications, such as bleeding or pneumothorax, particularly in cases where the biopsy is performed through lung tissue.
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