CPT® Code 38209

Transplant preparation of hematopoietic progenitor cells (HPCs) involves a critical process where previously harvested cells are thawed and treated for use in stem cell transplantation. Hematopoietic progenitor cells, also known as hematopoietic stem cells, are specialized cells found in the blood and bone marrow that possess the unique ability to develop into various types of mature blood cells, including red blood cells, platelets, and white blood cells. These cells play a vital role in the treatment of various medical conditions, particularly malignant neoplasms such as leukemia and lymphoma, as well as other disorders like sickle cell disease. The procedure associated with CPT® Code 38209 specifically refers to the thawing and washing of these cells from a single donor. The washing process is essential when multiple aliquots of harvested cells have been frozen over several days, as it helps to remove excess dimethyl sulfoxide (DMSO), a cryoprotectant that can become toxic in higher concentrations. By utilizing an automated cell washer, the cells are concentrated and resuspended in a suitable infusible solution, ensuring their viability and safety for transplantation. Following the washing, a quality assessment is conducted to confirm that the cells remain appropriate for use in the transplant procedure.