CPT® Code 38240

Hematopoietic progenitor cell (HPC) transplantation, commonly known as hematopoietic stem cell (HSC) transplantation, is a medical procedure that involves the infusion of progenitor cells into a recipient's bloodstream. These progenitor cells, which are essential for the formation of blood cells, can be sourced from various locations, including bone marrow, peripheral blood, or umbilical cord blood. The cells may be harvested from the patient themselves, referred to as autologous transplantation, or from a donor, known as allogeneic transplantation. In the case of allogeneic transplantation, the procedure is reported using CPT® Code 38240. Prior to the transplantation, the recipient undergoes a preparatory phase that includes myeloablative or immunosuppressive conditioning to create an optimal environment for the transplanted cells. Once the cells are harvested, they are typically frozen and stored until the transplantation is performed. During the actual procedure, the frozen hematopoietic progenitor cells are thawed, prepared, and then infused intravenously into the recipient. It is important to note that if multiple donors are involved in the transplantation process, CPT® Code 38240 should be reported for each allogeneic transplantation from a new donor. For cases involving autologous transplantation, CPT® Code 38241 is utilized instead.