CPT® Code 38243

Hematopoietic progenitor cell (HPC) transplantation, commonly known as hematopoietic stem cell (HSC) transplantation, is a medical procedure that involves the infusion of progenitor (stem) cells into a patient’s bloodstream. These progenitor cells can be sourced from various locations, including the bone marrow, peripheral blood, or umbilical cord blood. The cells may be harvested from the patient themselves, referred to as autologous transplantation, or from a donor, known as allogeneic transplantation. The collection of these cells typically occurs in a separate, reportable procedure prior to the main transplant. An important aspect of this procedure is the HPC 'boost,' which is an additional infusion of hematopoietic stem cells administered to patients who have recently undergone an HPC transplant and are experiencing complications such as poor graft function, graft failure, or graft rejection. This boost is distinct from a repeat transplant, as it does not necessitate the recipient undergoing any pre-transplant myeloablative or immunosuppressive conditioning, making it a targeted intervention aimed at enhancing the effectiveness of the initial transplant.