CPT® Code 42400

The procedure described by CPT® Code 42400 refers to a biopsy of the salivary gland using a needle. This type of biopsy is a minimally invasive technique employed to obtain tissue samples from the salivary gland for diagnostic purposes. The primary reasons for performing this biopsy include investigating the cause of gland enlargement, evaluating any lumps or masses present on the gland, and diagnosing conditions such as Sjogren's disease. Sjogren's disease is an autoimmune disorder that leads to a reduction in tear production, resulting in dry eyes, as well as decreased saliva production, causing dry mouth and dry mucous membranes. During the procedure, a core needle biopsy is conducted, which involves disinfecting the skin over the biopsy site and administering a local anesthetic to minimize discomfort. A small incision is made in the skin to facilitate the insertion of the needle into the salivary gland, allowing for the collection of a tissue sample. If a lump or mass is identified, imaging guidance may be utilized to accurately direct the needle to the appropriate location. The collected tissue sample is then prepared for histological evaluation, which is reported separately to assess the cellular characteristics of the tissue and aid in diagnosis.