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Official Description

Esophagoscopy, flexible, transoral; with directed submucosal injection(s), any substance

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 43201 refers to a flexible esophagoscopy performed transorally, which involves the use of a flexible endoscope to visualize the esophagus. This diagnostic procedure allows for a thorough examination of the esophagus, including the velopharyngeal closure, base of the tongue, and hypopharynx. During the esophagoscopy, the physician observes vocal cord motion and evaluates the pharyngeal musculature. The endoscope is introduced through the mouth and carefully advanced into the esophagus, reaching the gastroesophageal junction. Any abnormalities encountered during the procedure are meticulously noted. In addition to visual examination, the procedure may involve the collection of tissue specimens through brushing or washing techniques. In the context of CPT® Code 43201, the procedure is further enhanced by the inclusion of directed submucosal injection(s) of any substance. This step is crucial for various therapeutic and diagnostic purposes. Common substances used for injection include India ink, which is utilized for tattooing lesions to aid in their identification prior to excision, as well as saline, epinephrine, and corticosteroids. Saline or epinephrine injections serve to separate the mucosal layer from the muscle layer of the esophagus, facilitating the elevation of lesions for excision. Additionally, botulinum toxin is specifically indicated for the treatment of esophageal achalasia, where it is injected into the esophageal sphincter. The procedure may involve one or more submucosal injections, which are performed prior to any separately reportable lesion excision, thereby enhancing the overall effectiveness of the esophagoscopy.

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