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Official Description

Percutaneous nephrolithotomy or pyelolithotomy, lithotripsy, stone extraction, antegrade ureteroscopy, antegrade stent placement and nephrostomy tube placement, when performed, including imaging guidance; complex (eg, stone[s] > 2 cm, branching stones, stones in multiple locations, ureter stones, complicated anatomy)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 50081 involves a complex percutaneous nephrolithotomy or pyelolithotomy, which is a minimally invasive surgical technique used to remove renal calculi (kidney stones) that are larger than 2 cm, branching, or located in multiple areas of the kidney or ureter. This procedure is performed under imaging guidance, typically fluoroscopy, to ensure accurate placement of instruments and to visualize the stones during removal. The process begins with the cleansing of the skin over the planned puncture site, followed by the administration of a local anesthetic to minimize discomfort. A needle is then inserted through the skin into the kidney, allowing for the advancement of a guidewire and the placement of a sheath. A nephroscope is introduced through this sheath to visualize the stones, which are subsequently fragmented using various lithotripsy techniques, including ultrasound, electrohydraulics, pneumatic lithotripsy, or laser. The fragments are carefully extracted using forceps or suction. Additionally, antegrade ureteroscopy is performed to ensure that no stone fragments remain in the ureter, and any identified stones or fragments are removed. The procedure concludes with the placement of a nephrostomy tube to facilitate drainage, and the patient's fluid status and lung condition are monitored to prevent complications such as hydrothorax or pneumothorax. This comprehensive approach is essential for effectively managing complex stone disease in the renal system.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure described by CPT® Code 50081 is indicated for the following conditions:

  • Complex Renal Calculi The presence of stones larger than 2 cm in size, which may require advanced techniques for removal.
  • Branching Stones Stones that have multiple branches or extensions, complicating their removal.
  • Multiple Locations Stones located in various areas of the kidney or ureter, necessitating a comprehensive approach to ensure complete extraction.
  • Ureter Stones Stones that are situated within the ureter, which may require additional techniques to access and remove.
  • Complicated Anatomy Patients with anatomical variations that make standard stone removal techniques less effective or more challenging.

2. Procedure

The procedure involves several critical steps to ensure the effective removal of complex renal stones:

  • Preparation and Anesthesia The skin over the planned puncture site is thoroughly cleansed to reduce the risk of infection. A local anesthetic is then injected to numb the area, ensuring the patient experiences minimal discomfort during the procedure.
  • Puncture and Access A needle is carefully punctured through the skin and advanced into the kidney under fluoroscopic guidance. This imaging technique allows the physician to visualize the needle's trajectory and ensure accurate placement.
  • Guidewire and Sheath Placement Once the needle is correctly positioned, a guidewire is advanced through the needle into the kidney. A sheath is then placed over the guidewire, providing a pathway for further instruments.
  • Nephroscope Introduction A rigid nephroscope is introduced through the sheath, allowing the physician to visualize the renal calculus directly. This visualization is crucial for effective stone management.
  • Stone Fragmentation A handheld lithotripter is inserted through the nephroscope to fragment the stone. Various techniques, including ultrasound, electrohydraulics, pneumatic lithotripsy, or laser, may be employed to break the stone into smaller pieces for easier removal.
  • Fragment Removal The fragmented stone pieces are then removed using forceps or suction. For calyceal stones, a flexible nephroscope may be used to navigate through angulated areas, allowing for effective fragmentation and removal of stones using a laser and stone basket extractor.
  • Antegrade Ureteroscopy Following the removal of kidney stones, antegrade ureteroscopy is performed to ensure that no fragments remain in the ureter. A flexible ureteroscope is passed through the access sheath to the ureteropelvic junction and along the ureter, allowing for a thorough assessment.
  • Assessment and Fragment Removal The ureter is examined in its entirety for any primary stones, fragments, or potential injury. Small stones or fragments are removed using a basket extractor, while larger stones are fragmented with a laser fiber before removal or irrigation down the ureter.
  • Completion of Procedure Once all stones and fragments have been successfully removed, the nephroscope is withdrawn. A nephrostomy tube is then placed to facilitate drainage, and its positioning is verified to ensure effective post-procedural drainage.
  • Monitoring Throughout the procedure, the patient's fluid status and pressures are monitored, and the ipsilateral lung is checked for any signs of hydrothorax or pneumothorax, ensuring patient safety and addressing any complications promptly.

3. Post-Procedure

After the completion of the procedure, the patient will require careful monitoring to assess recovery and ensure proper drainage through the nephrostomy tube. The healthcare team will observe for any complications, such as bleeding, infection, or issues related to the nephrostomy tube placement. Patients may experience some discomfort or pain, which can be managed with appropriate analgesics. Follow-up imaging may be necessary to confirm the complete removal of stones and to evaluate the kidney's function. The healthcare provider will provide specific instructions regarding activity restrictions, hydration, and signs of potential complications that should prompt immediate medical attention.

Short Descr PERQ NL/PL LITHOTRP CPLX>2CM
Medium Descr PERQ NL/PL LITHOTRP COMPLEX >2 CM MLT LOCATIONS
Long Descr Percutaneous nephrolithotomy or pyelolithotomy, lithotripsy, stone extraction, antegrade ureteroscopy, antegrade stent placement and nephrostomy tube placement, when performed, including imaging guidance; complex (eg, stone[s] > 2 cm, branching stones, stones in multiple locations, ureter stones, complicated anatomy)
Status Code Active Code
Global Days 090 - Major Surgery
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 2 - Payment restriction for assistants at surgery does not apply to this procedure...
Co-Surgeons (62) 1 - Co-surgeons could be paid, though supporting documentation is required...
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P1G - Major procedure - Other
MUE 1
CCS Clinical Classification 103 - Nephrotomy and nephrostomy
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
GC This service has been performed in part by a resident under the direction of a teaching physician
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
62 Two surgeons: when 2 surgeons work together as primary surgeons performing distinct part(s) of a procedure, each surgeon should report his/her distinct operative work by adding modifier 62 to the procedure code and any associated add-on code(s) for that procedure as long as both surgeons continue to work together as primary surgeons. each surgeon should report the co-surgery once using the same procedure code. if additional procedure(s) (including add-on procedure(s) are performed during the same surgical session, separate code(s) may also be reported with modifier 62 added. note: if a co-surgeon acts as an assistant in the performance of additional procedure(s), other than those reported with the modifier 62, during the same surgical session, those services may be reported using separate procedure code(s) with modifier 80 or modifier 82 added, as appropriate.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
81 Minimum assistant surgeon: minimum surgical assistant services are identified by adding modifier 81 to the usual procedure number.
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2023-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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