Coding Ahead
CasePilot
Medical Coding Assistant
Case2Code
Search and Code Lookup Tool
CareerCenter
Medical Coding Job Board
Log in Register free account

Need help choosing the right code?

Ask CasePilot about procedures, modifiers, bundling, and coding guidance.

Try CasePilot

Official Description

Cystourethroscopy, with biopsy(s)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Cystourethroscopy is a diagnostic and therapeutic procedure that allows healthcare professionals to visualize the internal structures of the bladder and urethra. This procedure is essential for evaluating various urological conditions. During cystourethroscopy, a specialized instrument known as a cystoscope, which can be either rigid or flexible, is inserted through the urethra and into the bladder. The urethra is first cleansed with an antiseptic solution to minimize the risk of infection. To enhance visibility, the bladder may be filled with sterile saline, which helps to distend the bladder wall and provides a clearer view of its interior. The procedure involves a thorough inspection of the bladder, including the identification and examination of the ureteral orifices, which are the openings where the ureters enter the bladder. If any abnormalities are detected, biopsy forceps are introduced through the cystoscope to obtain tissue samples for further analysis. After the biopsy is performed, the bladder and urethra are re-inspected to ensure that there is no significant bleeding, and any bleeding that may have occurred is controlled before the cystoscope is carefully removed. This procedure is crucial for diagnosing conditions such as bladder tumors, inflammation, or other abnormalities within the urinary tract.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Indications for performing cystourethroscopy with biopsy include the following:

  • Bladder Tumors Evaluation of suspected tumors within the bladder to determine their nature and extent.
  • Hematuria Investigation of unexplained blood in the urine, which may indicate underlying pathology.
  • Urinary Tract Infections Assessment of recurrent urinary tract infections that do not respond to standard treatment.
  • Bladder Inflammation Examination of the bladder lining for signs of inflammation or other abnormalities.
  • Urethral Strictures Evaluation of narrowing in the urethra that may cause urinary obstruction.

2. Procedure

The procedure of cystourethroscopy with biopsy involves several key steps:

  • Preparation The patient is positioned comfortably, and the urethra is cleansed with an antiseptic solution to reduce the risk of infection.
  • Introduction of the Cystoscope A rigid or flexible cystoscope is carefully introduced through the urethra and advanced into the bladder. The choice of cystoscope type may depend on the specific clinical scenario and the physician's preference.
  • Bladder Distension Sterile saline may be instilled into the bladder to distend it, which enhances visualization of the bladder wall and allows for a more thorough examination.
  • Inspection The bladder is meticulously inspected, and the ureteral orifices are identified and examined for any abnormalities or lesions.
  • Biopsy If any suspicious areas are noted, biopsy forceps are introduced through the cystoscope to obtain tissue samples from the bladder wall for histological analysis.
  • Post-Biopsy Inspection After the biopsy is completed, the bladder and urethra are re-inspected to check for any bleeding or complications that may have arisen during the procedure.
  • Completion Any bleeding that is observed is controlled, and the cystoscope is then carefully removed from the urethra.

3. Post-Procedure

Following the cystourethroscopy with biopsy, patients may experience some discomfort, which is typically managed with analgesics. It is common for patients to have blood-tinged urine for a short period after the procedure. Patients are advised to drink plenty of fluids to help flush the bladder and reduce irritation. Follow-up appointments may be scheduled to discuss biopsy results and any further management that may be necessary based on the findings. It is important for patients to report any significant bleeding, fever, or worsening symptoms to their healthcare provider promptly.

Short Descr CYSTOSCOPY W/BIOPSY(S)
Medium Descr CYSTOURETHROSCOPY WITH BIOPSY
Long Descr Cystourethroscopy, with biopsy(s)
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 52000  Cystourethroscopy (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P8E - Endoscopy - cystoscopy
MUE 1
CCS Clinical Classification 100 - Endoscopy and endoscopic biopsy of the urinary tract

This is a primary code that can be used with these additional add-on codes.

C9738 Medicare Coverage: Special Coverage Instructions Add-on Code APC N ASC N1 Adjunctive blue light cystoscopy with fluorescent imaging agent (list separately in addition to code for primary procedure)
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GC This service has been performed in part by a resident under the direction of a teaching physician
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
SG Ambulatory surgical center (asc) facility service
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CR Catastrophe/disaster related
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
AG Primary physician
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
ET Emergency services
GA Waiver of liability statement issued as required by payer policy, individual case
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
LT Left side (used to identify procedures performed on the left side of the body)
PT Colorectal cancer screening test; converted to diagnostic test or other procedure
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RT Right side (used to identify procedures performed on the right side of the body)
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
Date
Action
Notes
2011-01-01 Changed Medium description changed.
2007-01-01 Changed Code description changed.
Pre-1990 Added Code added.
Code
Description
Code
Description
Code
Description
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"