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Official Description

Biopsy of penis; deep structures

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

A biopsy of the penis is a medical procedure that involves the removal of tissue from the deeper structures of the penis for diagnostic purposes. This procedure is typically indicated when there is a suspicious mass or lesion that requires further investigation to determine its nature, such as the presence of cancer or other pathological conditions. In contrast to a simple biopsy, which involves the removal of superficial tissue, the procedure associated with CPT® Code 54105 entails a more invasive approach. The area to be biopsied is first disinfected to minimize the risk of infection, and a local anesthetic may be administered to ensure patient comfort during the procedure. However, in some cases, particularly when deeper structures are involved, a general anesthetic may be necessary. The surgeon makes an incision in the skin over the lesion and carefully dissects the overlying tissues to expose the suspicious mass. Once the mass is accessible, a tissue sample is obtained and sent to a laboratory for histological evaluation, which is reported separately. This detailed examination of the tissue sample is crucial for accurate diagnosis and subsequent treatment planning.

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