© Copyright 2026 American Medical Association. All rights reserved.
The procedure described by CPT® Code 54110 involves the excision of penile plaque associated with Peyronie's disease. Peyronie's disease is a medical condition characterized by the formation of a hard, fibrous layer of scar tissue, known as plaque, which develops beneath the skin in the spongy erectile tissue of the penis. This plaque can lead to a curvature of the penis during an erection, causing discomfort and potential difficulties with sexual function. The excision procedure aims to remove this plaque to alleviate the curvature and restore normal function. During the procedure, the overlying tissue is carefully incised to expose the plaque. The surgeon may then either expand the plaque by making several linear cuts or excise it entirely. Depending on the extent of the excision, the areas may be covered with a graft, which can be made from skin, vein, or synthetic material. It is important to note that the specific CPT® codes used will depend on whether the procedure is performed with or without graft repair, with additional codes available for grafts of varying sizes.
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