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Official Description

Injection procedure for Peyronie disease;

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Peyronie's disease is a condition that affects the penis, characterized by the formation of a hard, fibrous layer of scar tissue, known as plaque, beneath the skin in the spongy erectile tissue. This plaque can lead to a curvature of the penis during an erection, which may cause discomfort and difficulties during sexual intercourse. The injection procedure described by CPT® Code 54200 is a minimally invasive treatment option aimed at addressing this condition. During the procedure, a physician administers an injectable medication that targets the scar tissue, promoting its breakdown and facilitating the regeneration of normal tissue. Commonly used medications for this injection include collagenase, which specifically breaks down collagen in the plaque, as well as calcium channel blockers like verapamil and interferons, which may help in reducing the size of the plaque. The injections are typically performed at multiple sites on the affected side of the penis, allowing for a more effective treatment of the curvature caused by Peyronie's disease. This procedure can be performed with or without surgical exposure of the plaque, depending on the specific circumstances and the approach taken by the physician.

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