CPT® Code 54205

Peyronie's disease is a condition that affects the penis, characterized by the formation of a hard, fibrous layer of scar tissue known as plaque. This plaque develops in the spongy erectile tissue, which can be located on either the upper or lower side of the penis. The presence of this plaque can lead to a curvature of the penis during an erection, causing discomfort and potential difficulties with sexual function. The injection procedure for Peyronie's disease, identified by CPT® Code 54205, involves a more invasive approach than other treatment options. In this procedure, the physician performs a surgical exposure of the plaque, which allows for direct access to the affected area. Following the surgical exposure, a drug is injected into the plaque at multiple sites. This method aims to break down the scar tissue and promote the regeneration of normal tissue, thereby addressing the curvature and restoring function. Commonly used medications for this injection include collagenase, calcium channel blockers such as verapamil, and interferons, which are administered directly into the plaque to enhance treatment efficacy.