© Copyright 2026 American Medical Association. All rights reserved.
A transperineal needle biopsy of the prostate is a medical procedure that involves the extraction of tissue samples from the prostate gland for diagnostic purposes. This procedure is performed using a technique known as stereotactic template-guided saturation sampling, which ensures precise targeting of the prostate tissue. The process begins with the use of transrectal ultrasound (TRUS) to visualize the prostate and guide the biopsy needle accurately. A stereotactic template is then employed, which is a specialized device that helps in positioning the prostate on an implant grid. This grid is systematically divided into six or more sections, allowing for comprehensive sampling of the prostate tissue. A linear probe, equipped with a needle guidance attachment, is utilized to facilitate the collection of tissue samples from each designated section of the prostate. During the procedure, multiple tissue cores—potentially up to 60—are harvested and placed into separate specimen jars, each corresponding to the specific section from which the sample was taken. These samples are subsequently sent to a laboratory for pathology analysis, where they are examined for any signs of disease, such as cancer. This method of biopsy is particularly beneficial as it maximizes the chances of detecting abnormalities within the prostate by ensuring thorough sampling across multiple areas of the gland.
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