© Copyright 2026 American Medical Association. All rights reserved.
Cordocentesis, also referred to as percutaneous umbilical blood sampling (PUBS), is a medical procedure performed to obtain fetal blood for diagnostic purposes. This procedure is typically conducted during pregnancy when there is a need to assess the health of the fetus, particularly in cases where genetic or hematological disorders are suspected. The process involves the physician using ultrasonic guidance to accurately locate the umbilical cord and the fetal blood vessels. A needle is then carefully inserted through the abdominal wall into either the umbilical artery or vein, allowing for the aspiration of fetal blood. This blood sample can provide critical information regarding the fetus's condition, including blood type, hemoglobin levels, and the presence of infections or genetic abnormalities. The physician may choose to employ either a transamniotic approach, where the needle passes through the amniotic sac, or a transplacental approach, where the needle traverses the placenta, depending on the specific clinical scenario. After the blood sample is collected, the needle is removed, completing the procedure.
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