© Copyright 2026 American Medical Association. All rights reserved.
The sphenopalatine ganglion, also known by various names such as the pterygopalatine ganglion, nasal ganglion, Meckel's ganglion, or SPG, is a small but significant cluster of nerves that encompasses sympathetic, parasympathetic, and sensory nerve fibers. This ganglion plays a crucial role in the autonomic nervous system and is located posterior to the nasal cavity. The procedure associated with CPT® code 64505 involves the injection of a local anesthetic agent directly into the sphenopalatine ganglion. This targeted approach is utilized primarily for the management of headaches stemming from various causes, as well as for conditions such as trigeminal neuralgia, which is characterized by severe facial pain. It is important to note that the technique described by this code specifically refers to the injection method, which involves the insertion of a needle through the cheek to reach the ganglion. Alternative methods, such as the use of an anesthetic-coated cotton swab applied intranasally or the SphenoCath catheter technique, do not qualify as injections and therefore do not fall under the description of code 64505. These alternative techniques may be reported differently, either as part of an evaluation and management (E/M) service or using the unlisted code 64999.
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