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Official Description

Destruction by neurolytic agent, trigeminal nerve; supraorbital, infraorbital, mental, or inferior alveolar branch

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 64600 involves the destruction of specific branches of the trigeminal nerve, namely the supraorbital, infraorbital, mental, or inferior alveolar branches. This intervention is primarily aimed at alleviating chronic pain conditions associated with these nerve pathways. The destruction can be achieved through various techniques, including the injection of a neurolytic agent or the application of thermal, electrical, or radiofrequency methods. Among these, radiofrequency destruction is the most commonly utilized technique in contemporary practice due to its effectiveness in targeting nerve tissue. Prior to the actual destruction, a precise approach is taken where an electrode needle is inserted through the skin and directed towards the affected neural tissue. This needle is connected to a generator that facilitates motor and sensory testing, ensuring accurate placement at the nerve responsible for the patient's pain. Once the correct nerve is identified, the destruction process is initiated. If a chemical neurolytic agent is employed, it is injected along the nerve pathway to achieve the desired effect. Common neurolytic agents include phenol, ethyl alcohol, glycerol, ammonium salt compounds, and various hypertonic or hypotonic solutions. Alternatively, thermal or electrical modalities utilize a probe or needle that, once inserted, generates heat to destroy the nerve tissue. In the case of radiofrequency nerve destruction, the electrode needle is carefully positioned, and upon activation of the radiofrequency device, an electric current is produced that generates heat at the electrode's tip, effectively destroying the targeted nerve tissue. This procedure is specifically coded as 64600 for the destruction of the aforementioned branches of the trigeminal nerve.

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