CPT® Code 64615

Chemodenervation of muscle(s); muscle(s) innervated by facial, trigeminal, cervical spinal and accessory nerves, bilateral (eg, for chronic migraine)

CPT® Code 64615 refers to the procedure known as chemodenervation of muscle(s) that are innervated by the facial, trigeminal, cervical spinal, and accessory nerves, performed bilaterally. This procedure is commonly utilized for the management of chronic migraines. Chemodenervation is a technique that involves the injection of a neurotoxin, specifically type A botulinum toxin, directly into targeted muscles. The primary mechanism of action is the temporary paralysis of these muscles, achieved by blocking the release of acetylcholine, a neurotransmitter that plays a crucial role in muscle contraction. By inhibiting acetylcholine release, the procedure effectively reduces muscle contractions and alleviates pain associated with migraines. The injection sites typically include the muscles of the forehead, as well as those located on the sides and back of the head, neck, and shoulders, allowing for a comprehensive approach to migraine prevention. This method has been supported by clinical evidence demonstrating its efficacy in reducing the frequency and severity of migraine attacks.