© Copyright 2026 American Medical Association. All rights reserved.
Chemodenervation refers to a medical procedure aimed at reducing involuntary muscle contractions or spasms, particularly in the trunk muscles. This technique is commonly utilized for patients suffering from conditions such as dystonia, cerebral palsy, or multiple sclerosis, where muscle control is compromised. The procedure involves the injection of botulinum toxin, either type A or B, directly into the targeted muscles. This toxin works by temporarily paralyzing the muscle, effectively blocking the release of acetylcholine at the peripheral nerve endings. By interrupting the neuromuscular transmission of nerve impulses, the procedure alleviates the symptoms associated with muscle spasms. Prior to the injections, the specific muscles to be treated are identified through methods such as electromyography or physical examination, which includes palpating the muscles and assessing the areas of spasm. The trunk is then prepared for the procedure, ensuring a sterile environment. The injections are administered at carefully selected sites within the affected muscle or muscle group to achieve optimal denervation. It is important to note that CPT® Code 64647 is specifically designated for cases involving six or more trunk muscles, while CPT® Code 64646 is used for procedures involving one to five trunk muscles.
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