© Copyright 2026 American Medical Association. All rights reserved.
Excision of a lesion from the sclera, as described by CPT® Code 66130, involves the surgical removal of abnormal growths or lesions located on the sclera, which is the white outer coating of the eyeball. These lesions are typically benign and can manifest in various forms, including pingueculae, which are yellowish, slightly elevated growths commonly found in the area between the eyelids. Additionally, pigmented lesions may arise from melanocytes or non-melanocytes and can be either congenital or acquired. The removal of scleral lesions may be indicated for cosmetic reasons or if the lesions increase in size and cause discomfort to the patient. The procedure is performed under local anesthesia, utilizing a topical ophthalmic anesthetic to ensure patient comfort. The surgical site is prepared with an antibacterial solution to minimize the risk of infection. An eyelid speculum is then inserted to keep the eyelids open during the procedure, allowing for clear access to the lesion. Following the excision, there may be a need for tissue grafting to repair any surgical defect created by the removal of the lesion. To further enhance the outcome, a cytotoxic drug known as Mitomycin C may be applied briefly to the area to help reduce scarring before being flushed away, ensuring optimal healing and cosmetic results.
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