CPT® Code 76978

Ultrasound, targeted dynamic microbubble sonographic contrast characterization (non-cardiac) is a specialized imaging technique that enhances the visualization of certain organs or tissues through the use of microbubble contrast agents. These agents consist of tiny gas-filled bubbles that are encased in a stable shell made of lipids, proteins, or polymers. The microbubbles are designed to be tagged with ligands that specifically bind to certain receptors present in the targeted tissues. When these microbubbles are injected intravenously, they travel through the bloodstream and accumulate in areas where the receptors are present. This accumulation alters the way ultrasound waves interact with the tissue, resulting in increased echogenicity, which allows for improved imaging of the targeted area. This technique is particularly useful for identifying and characterizing lesions, such as tumors and nodules, in organs like the liver, pancreas, kidneys, and ovaries. Additionally, it can be employed to evaluate inflammatory lesions and tumors in the gastrointestinal tract, as well as to assess abdominal parenchyma for conditions such as hematomas and vascular injuries following trauma. The CPT® Code 76978 specifically reports the initial characterization of a non-cardiac lesion using this advanced ultrasound technique, while CPT® Code 76979 is used for reporting each additional lesion that requires a separate injection of the contrast agent.