© Copyright 2026 American Medical Association. All rights reserved.
Hyperthermia generated by intracavitary probe(s) is a specialized medical procedure aimed at increasing the temperature of tumor cells while minimizing damage to surrounding healthy tissue. This technique utilizes probes that are inserted into body cavities, where they generate heat through various methods such as microwave, radiofrequency, or ultrasound. The fundamental principle behind this procedure is that tumor cells exhibit a higher sensitivity to elevated temperatures compared to normal cells. By raising the temperature of the tumor cells, the procedure can enhance the efficacy of concurrent treatments like radiation and chemotherapy, as well as potentially stimulate the immune system to target and destroy abnormal cells more effectively. Intracavitary hyperthermia is particularly applicable for tumors that are accessible through natural body openings, including the vagina for cervical and uterine tumors, the anus for prostate tumors, the nose for nasopharyngeal tumors, and the mouth for esophageal tumors. During the procedure, a specially designed probe that conforms to the shape of the cavity is carefully inserted, with its placement often confirmed through imaging techniques such as x-ray or ultrasound. Once positioned, a heat source is introduced into the probe, elevating the temperature of the targeted area to the predetermined therapeutic level. Upon completion of the hyperthermia session, the probe and heat source are removed from the body cavity. This CPT® code encompasses not only the hyperthermia treatment itself but also includes the management of the treatment course, physics planning, insertion of temperature sensors, and the utilization of heat-generating devices.
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