CPT® Code 78140

Labeled red cell sequestration of differential organs/tissue is a diagnostic test that evaluates the rate at which red blood cells (RBCs) are removed from the bloodstream. This procedure is particularly useful in identifying conditions where there is an abnormal accumulation of RBCs in specific organs or tissues, such as the spleen or liver. A notable increase in the RBC ratio over time can indicate that these organs are sequestering red blood cells, which may lead to complications such as organ enlargement and potential rupture. Symptoms associated with this sequestration can include pain resulting from the swelling of the affected organ or tissue. This test is instrumental in diagnosing various hematological disorders, including hereditary spherocytosis, acquired hemolytic anemia, and hemolytic anemia linked to malignancies such as lymphoma or leukemia. Furthermore, the results of this test can inform treatment decisions, including the consideration of surgical options like splenectomy. The procedure involves the withdrawal of blood from the patient, followed by the tagging of RBCs with a radioactive isotope, which allows for the tracking of these cells as they circulate and are sequestered by the organs. The subsequent imaging process provides critical insights into the dynamics of RBC sequestration and the health of the involved organs.