© Copyright 2026 American Medical Association. All rights reserved.
Liver imaging using single-photon emission computed tomography (SPECT) is a diagnostic procedure that employs a radiolabeled isotope tracer, specifically 99mTC-sulfur colloid, to visualize the liver's structure and function. This advanced imaging technique is particularly useful for identifying small lesions that may not be visible through traditional planar imaging methods. It is also employed to evaluate liver masses or lesions that have been detected through other imaging modalities such as computed tomography (CT), ultrasound (US), or magnetic resonance imaging (MRI). Additionally, SPECT imaging plays a critical role in monitoring conditions such as cirrhosis and hepatitis C infection, which can significantly affect liver health. The liver, located in the upper right quadrant of the abdomen, is a vital organ responsible for various functions, including bile production, nutrient metabolism, drug and toxin removal from the bloodstream, and the synthesis of proteins essential for blood plasma and clotting regulation. The liver's complex structure consists of two main lobes and numerous smaller lobules interconnected by a network of ducts that facilitate bile drainage into larger ducts, ultimately leading to the hepatic duct. The bile produced by the liver contains enzymes that aid in fat breakdown and transport waste materials to the gallbladder and duodenum. During the SPECT procedure, an intravenous line is established to administer the radiolabeled tracer, which allows for the capture of detailed, three-dimensional images of the liver as gamma cameras rotate around the patient. The imaging process involves scanning at specific intervals to detect the radioactive energy emitted from the liver, which is then converted into visual representations for analysis. It is important to note that when assessing vascular flow in the liver, a different code, 78206, is utilized, as the liver's extensive vascular network, including the portal vein and hepatic artery, can exhibit changes in blood flow due to vessel compromise. Following the imaging, the physician interprets the SPECT results and generates a comprehensive written report detailing the findings.
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