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Code deleted, see 80300, 80301, 80302, 80303, 80304

Official Description

Drug screen, qualitative; multiple drug classes chromatographic method, each procedure

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

A qualitative drug screen is a laboratory procedure designed to detect the presence or absence of multiple drug classes in a specimen using a chromatographic method, as indicated by CPT® Code 80100. This type of drug screening does not measure the quantity or concentration of the drugs; rather, it simply identifies whether specific drugs or drug classes are present in the sample. The specimens used for this testing can include blood serum, urine, saliva, sweat, hair, or other biological materials. The chromatographic method, particularly thin layer chromatography (TLC), is the most commonly employed technique for testing multiple drug classes. In this method, a small amount of the specimen is applied to a plate coated with an organic binder. The plate is then positioned vertically, and the bottom is immersed in a solvent. As the solvent ascends the plate, it carries the components of the specimen with it, allowing for the separation of heavier and lighter substances. The resulting streaks or spots are visualized using ultraviolet light or a chemical spray and are compared against established chromatogram standards to identify specific drug classes. Each procedure performed under this code is reported separately, ensuring accurate documentation and billing for the qualitative analysis conducted.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The qualitative drug screen using CPT® Code 80100 is indicated for the detection of multiple drug classes in various clinical scenarios. The following conditions may warrant the use of this procedure:

  • Substance Abuse Evaluation This procedure is often performed to assess individuals for potential substance abuse issues, providing critical information for treatment and intervention.
  • Pre-Employment Screening Employers may require drug screening as part of the hiring process to ensure a drug-free workplace.
  • Monitoring Treatment Compliance Patients undergoing treatment for substance use disorders may be regularly screened to monitor compliance with prescribed therapies.
  • Legal and Forensic Testing Drug screens may be utilized in legal contexts, such as probation monitoring or custody disputes, to provide evidence of drug use.

2. Procedure

The procedure for conducting a qualitative drug screen using the chromatographic method involves several key steps, which are detailed below:

  • Specimen Collection A specimen, such as urine, blood serum, saliva, sweat, or hair, is collected from the patient. Proper collection techniques must be followed to ensure the integrity of the sample.
  • Preparation of the Chromatography Plate A small amount of the collected specimen is applied to a chromatography plate that has been pre-coated with an organic binder. This preparation is crucial for the subsequent separation of drug components.
  • Solvent Application The chromatography plate is positioned vertically, and the bottom edge is immersed in a solvent. The solvent travels up the plate, carrying the specimen with it and facilitating the separation of different components based on their molecular weight and affinity for the binder.
  • Visualization of Results After the solvent has ascended the plate, an ultraviolet light or chemical spray is applied to visualize the separated components. This step allows for the identification of streaks or spots corresponding to specific drug classes.
  • Comparison to Standards The visualized results are compared against established chromatogram standards to determine the presence of specific drugs or drug classes in the specimen.
  • Reporting Each procedure performed is reported using CPT® Code 80100, ensuring accurate documentation for billing and compliance purposes.

3. Post-Procedure

After the qualitative drug screen is completed, the results are typically reviewed and interpreted by a qualified laboratory professional. If the test indicates the presence of drugs, further confirmatory testing may be required to validate the results. Patients may be advised on the next steps based on the findings, which could include counseling, treatment options, or legal implications depending on the context of the testing. It is essential to maintain proper documentation of the procedure and results for compliance and billing purposes.

Short Descr DRUG SCREEN QUALITATE/MULTI
Medium Descr DRUG SCR QUAL MLT DRUG CLASSES CHROM EA PX
Long Descr Drug screen, qualitative; multiple drug classes chromatographic method, each procedure
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 206 - Microscopic examination (bacterial smear, culture, toxicology)
Date
Action
Notes
2015-01-01 Deleted Code deleted, see 80300, 80301, 80302, 80303, 80304
2011-01-01 Changed Short description changed.
2001-01-01 Changed Code description changed.
1993-01-01 Added First appearance in code book in 1993.
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Description
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