Coding Ahead
CasePilot
Medical Coding Assistant
Case2Code
Search and Code Lookup Tool
CareerCenter
Medical Coding Job Board
Log in Register free account

Need help choosing the right code?

Ask CasePilot about procedures, modifiers, bundling, and coding guidance.

Try CasePilot
Code deleted, see 80300, 80301, 80302, 80303, 80304

Official Description

Drug confirmation, each procedure

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

A drug confirmation test is a laboratory procedure conducted to verify the presence of specific drugs in a biological specimen, typically following a positive result from an initial screening test. This confirmation is crucial for accurate diagnosis and treatment, as it ensures that the detected substances are indeed present and not false positives. The most prevalent method employed for drug confirmation is gas chromatography/mass spectrometry (GC/MS). In the gas chromatography phase, the specimen is vaporized and its components are separated as they travel through a tube. Different substances move at varying speeds, allowing for the identification of each component based on its travel time, which is recorded by a sensor. This process generates a chromatogram, a graphical representation that provides a detailed chemical profile of the substances present in the specimen. The mass spectrometry phase further refines this identification by ionizing the vapors and subjecting them to a magnetic field. The ions produced travel different distances based on their mass, with heavier ions traveling shorter distances. This results in an ion spectrum that accurately identifies the specific drugs present in the specimen, making the drug confirmation test a highly reliable method for substance verification.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The drug confirmation test is indicated in various scenarios where the presence of drugs needs to be verified following an initial positive screening. The following conditions may warrant the performance of this procedure:

  • Positive Screening Test A drug confirmation test is performed after a positive result from a preliminary drug screening, ensuring the accuracy of the initial findings.
  • Substance Abuse Evaluation This test is often utilized in the assessment of individuals suspected of substance abuse, providing definitive evidence of drug presence.
  • Medication Monitoring It may be indicated for monitoring patients on prescribed medications to ensure compliance and detect any unauthorized drug use.
  • Legal and Forensic Testing Drug confirmation tests are frequently required in legal contexts, such as court cases or employment screenings, to confirm drug use.

2. Procedure

The procedure for drug confirmation testing involves several critical steps to ensure accurate results. Each step is designed to meticulously analyze the specimen for the presence of drugs.

  • Specimen Collection The first step involves the collection of a biological specimen, which may include urine, blood, or saliva, depending on the testing requirements. Proper collection techniques are essential to avoid contamination and ensure the integrity of the sample.
  • Initial Screening Before confirmation testing, an initial screening test is conducted. This preliminary test identifies potential drug presence and determines whether further confirmation is necessary.
  • Gas Chromatography In the confirmation phase, the specimen undergoes gas chromatography. The sample is vaporized and passed through a tube where its components are separated based on their travel speeds. The sensor records the elution time, generating a chromatogram that visually represents the substances present.
  • Mass Spectrometry Following gas chromatography, mass spectrometry is employed. The vapors are ionized and subjected to a magnetic field, where ions are separated based on their mass. The resulting ion spectrum provides a precise identification of the drugs present in the specimen.

3. Post-Procedure

After the drug confirmation test is completed, the results are analyzed and interpreted by qualified laboratory personnel. The findings are then documented and reported to the requesting physician or healthcare provider. It is essential to ensure that the results are communicated clearly, as they may influence treatment decisions or legal outcomes. Patients may be advised on the next steps based on the confirmation results, which could include further evaluation, counseling, or changes in medication management. Additionally, proper storage and handling of the specimen and results are crucial for maintaining the integrity of the testing process.

Short Descr DRUG CONFIRMATION
Medium Descr DRUG CONFIRMATION EACH PROCEDURE
Long Descr Drug confirmation, each procedure
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 206 - Microscopic examination (bacterial smear, culture, toxicology)
Date
Action
Notes
2015-01-01 Deleted Code deleted, see 80300, 80301, 80302, 80303, 80304
2001-01-01 Changed Code description changed.
1993-01-01 Added First appearance in code book in 1993.
Code
Description
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"