CPT® Code 80162

The CPT® Code 80162 refers to a laboratory test specifically designed to measure total digoxin levels in the blood. Digoxin, commonly known by its brand name Lanoxin, is classified as a cardiac glycoside, a type of medication that plays a crucial role in managing various heart conditions. It works by regulating sodium and potassium levels within cardiac cells, which is essential for proper heart function. This medication is primarily prescribed for patients suffering from atrial fibrillation, atrial flutter, and congestive heart failure. By increasing the strength of cardiac muscle contractions, digoxin enhances cardiac output, effectively lowering heart rate and venous pressure. However, it is important to note that digoxin has a narrow therapeutic window, meaning that the difference between an effective dose and a toxic dose is small. In cases of digoxin toxicity, antidotal treatment is available, such as Digibind or Digoxin Immune FAB. The total digoxin test (CPT® Code 80162) measures both the inactive digoxin that is bound to Fab fragments and the active free digoxin in the serum. This test is primarily utilized to monitor patients undergoing digoxin therapy and is recommended to be performed 8-12 hours after an oral dose to ensure accurate measurement. Additionally, there is a related test for free digoxin (CPT® Code 80163), which is used to assess breakthrough digoxin toxicity, particularly in patients with renal failure, and to guide further treatment decisions. The testing process involves obtaining a blood sample, with total digoxin levels measured using immunoassay techniques, while free digoxin levels are determined through ultrafiltration followed by electrochemiluminescent immunoassay.