CPT® Code 80235

The CPT® Code 80235 refers to a laboratory test specifically designed to monitor therapeutic drug levels of lacosamide. Lacosamide is an anti-epileptic medication primarily utilized in the treatment of partial-onset seizures in patients aged 4 years and older, as well as for managing peripheral neuropathy. The mechanism of action for lacosamide involves the selective enhancement of slow inactivation of sodium channels located in brain synapses. Additionally, it interacts with a neuroplasticity-relevant target known as collapsin-response mediator protein-2 (CRMP-2), which plays a role in neuronal signaling and plasticity. When administered, peak levels of lacosamide are typically reached approximately one hour following intravenous infusion and around four hours after oral administration. The drug has a half-life of about 13 hours, which necessitates a dosing regimen of twice daily to effectively prevent breakthrough seizures in patients. Lacosamide is metabolized in the liver and subsequently excreted through urine, making monitoring of its levels crucial for ensuring therapeutic efficacy and safety. To assess the drug levels, a blood sample is collected, which is reported as a separate procedure. The serum is then analyzed for peak levels within 1 to 4 hours post-dose administration and for trough levels 12 hours after the last dose, utilizing a sophisticated testing method known as liquid chromatography/tandem mass spectrometry (LC/MS-MS). This detailed monitoring is essential for optimizing treatment and minimizing potential side effects associated with lacosamide therapy.