Need help choosing the right code?
Ask CasePilot about procedures, modifiers, bundling, and coding guidance.
Try CasePilot© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 80340 refers to a laboratory test specifically designed to measure the levels of antiepileptic drugs that are not otherwise specified. Antiepileptics are a class of medications primarily utilized in the management of seizure disorders, which are neurological conditions characterized by abnormal electrical activity in the brain. In addition to their primary use in treating seizures, these medications may also be prescribed for patients suffering from chronic pain conditions, such as migraines or fibromyalgia. The pharmacological action of antiepileptics can vary significantly among different drugs within this category; however, they generally work by altering the activity of various brain chemicals. This includes modulation of sodium channels, GABA (gamma-aminobutyric acid) receptors, NMDA (N-methyl-D-aspartate) receptors, calcium channels, AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, and potassium channels. By influencing these pathways, antiepileptics help to reduce the frequency of abnormal electrical discharges in the brain, which can lead to seizures or pain sensations. The primary analytical methods employed for testing the presence and levels of these drugs in biological samples, such as urine, serum, or plasma, include high-performance liquid chromatography, gas chromatography, liquid chromatography-tandem mass spectrometry, and immunoassays. It is important to note that CPT® Code 80339 is applicable when testing for 1-3 antiepileptic drugs, while CPT® Code 80341 is designated for evaluations involving 7 or more antiepileptic compounds.
© Copyright 2026 Coding Ahead. All rights reserved.
The CPT® Code 80340 is indicated for use in situations where there is a need to measure the levels of antiepileptic drugs in a patient's system. This testing is particularly relevant for patients who are undergoing treatment for seizure disorders, as it helps to monitor therapeutic drug levels and ensure effective management of their condition. Additionally, this code may be applicable for patients with chronic pain conditions, such as migraines or fibromyalgia, where antiepileptics are utilized as part of their treatment regimen. The measurement of these drug levels can assist healthcare providers in making informed decisions regarding medication adjustments, adherence to prescribed therapy, and the overall effectiveness of the treatment plan.
The procedure associated with CPT® Code 80340 involves several key steps to accurately measure the levels of 4-6 antiepileptic compounds in a biological sample. The first step typically includes the collection of a biological specimen, which may be urine, serum, or plasma, depending on the specific requirements of the test. Once the sample is collected, it is prepared for analysis, which may involve processes such as centrifugation to separate the plasma or serum from the cellular components of the blood. Following sample preparation, the analytical method is selected based on the laboratory's capabilities and the specific antiepileptic drugs being tested. Common methods include high-performance liquid chromatography, gas chromatography, liquid chromatography-tandem mass spectrometry, and immunoassays. Each of these methods has its own protocols for calibration, quality control, and validation to ensure accurate and reliable results. After the analysis is completed, the results are compiled and reported, providing healthcare providers with critical information regarding the patient's drug levels, which can inform treatment decisions and adjustments.
After the procedure associated with CPT® Code 80340, healthcare providers will review the test results to assess the levels of antiepileptic drugs in the patient's system. This information is crucial for determining whether the current medication regimen is effective or if adjustments are necessary. Patients may be monitored for any side effects or adverse reactions related to their antiepileptic medications, and follow-up appointments may be scheduled to discuss the results and any changes to the treatment plan. Additionally, it is important for healthcare providers to ensure that patients understand the significance of adhering to their prescribed medication regimen, as this can impact the overall management of their seizure disorders or chronic pain conditions.
| Short Descr | ANTIEPILEPTICS NOS 4-6 | Medium Descr | ANTIEPILEPTICS NOT OTHERWISE SPECIFIED 4-6 | Long Descr | Antiepileptics, not otherwise specified; 4-6 | Status Code | Not Valid for Medicare Purposes | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Code Not Recognized by OPPS when submitted on Outpatient Hospital Part B Bill Type (12x/13x) | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T2D - Other tests - other | MUE | 1 |
|
Date
|
Action
|
Notes
|
|---|---|---|
| 2015-01-01 | Added | Added |
Get instant expert-level medical coding assistance.