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Official Description

Antipsychotics, not otherwise specified; 1-3

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80342 refers to a laboratory test specifically designed to measure the levels of antipsychotic medications that are not otherwise specified. Antipsychotics are a class of neuroleptic drugs that primarily influence neurotransmitters in the brain, particularly dopamine and serotonin, which play crucial roles in mood regulation and thought processes. These medications are commonly utilized in the treatment of psychotic disorders, such as schizophrenia and bipolar disorder, where patients may experience symptoms like delusions, hallucinations, and disordered thinking. While antipsychotic medications do not provide a cure for these mental health conditions, they are effective in significantly managing and controlling the associated symptoms, thereby improving the quality of life for individuals affected by these disorders. The testing for antipsychotics can be conducted using various analytical methods, including gas chromatography, gas chromatography-mass spectrometry, high-performance liquid chromatography, and liquid chromatography-tandem mass spectrometry. The specific code 80342 is applicable when the laboratory test is focused on detecting 1 to 3 different antipsychotic compounds in a sample, such as urine, serum, or plasma. For tests involving a higher number of compounds, different codes are utilized, with code 80343 designated for 4 to 6 compounds and code 80344 for 7 or more antipsychotic drugs.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The laboratory test represented by CPT® Code 80342 is indicated for the measurement of antipsychotic medications in patients who may be undergoing treatment for various psychiatric conditions. The specific indications for this test include:

  • Monitoring Treatment Efficacy This test is used to assess the levels of antipsychotic medications in patients diagnosed with schizophrenia or bipolar disorder to ensure that the treatment regimen is effective in managing their symptoms.
  • Assessing Compliance The test can help determine whether patients are adhering to their prescribed medication regimen, which is crucial for effective management of their psychiatric conditions.
  • Evaluating Side Effects In cases where patients exhibit adverse reactions or side effects, this test can assist healthcare providers in adjusting dosages or changing medications as necessary.

2. Procedure

The procedure for conducting the laboratory test associated with CPT® Code 80342 involves several key steps, which are outlined as follows:

  • Sample Collection A biological sample, typically urine, serum, or plasma, is collected from the patient. The choice of sample type may depend on the specific clinical scenario and the antipsychotic medications being tested.
  • Sample Preparation The collected sample undergoes preparation to isolate the antipsychotic compounds. This may involve processes such as centrifugation or filtration to ensure that the sample is suitable for analysis.
  • Analytical Testing The prepared sample is subjected to one of several analytical methods, such as gas chromatography, gas chromatography-mass spectrometry, high-performance liquid chromatography, or liquid chromatography-tandem mass spectrometry. These methods are employed to accurately identify and quantify the presence of 1 to 3 antipsychotic medications in the sample.
  • Result Interpretation Once the analysis is complete, the results are interpreted by qualified laboratory personnel. The findings are then compiled into a report that details the levels of the detected antipsychotic medications.
  • Reporting The final report is communicated to the healthcare provider, who will use the information to make informed decisions regarding the patient's treatment plan.

3. Post-Procedure

After the laboratory test associated with CPT® Code 80342 is completed, there are several considerations for post-procedure care. Patients may not require any specific post-procedure care as the test involves a non-invasive sample collection. However, healthcare providers should review the test results promptly to assess the patient's medication levels and make any necessary adjustments to their treatment plan. It is also important for providers to discuss the results with the patient, addressing any concerns regarding medication adherence, side effects, or the overall management of their psychiatric condition. Continuous monitoring and follow-up testing may be recommended based on the patient's response to treatment and any changes in their clinical status.

Short Descr ANTIPSYCHOTICS NOS 1-3
Medium Descr ANTIPSYCHOTICS NOT OTHERWISE SPECIFIED 1-3
Long Descr Antipsychotics, not otherwise specified; 1-3
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Code Not Recognized by OPPS when submitted on Outpatient Hospital Part B Bill Type (12x/13x)
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T2D - Other tests - other
MUE 1
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
2015-01-01 Added Added
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