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Official Description

Drug(s) or substance(s), definitive, qualitative or quantitative, not otherwise specified; 7 or more

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80377 refers to a laboratory test that is conducted to definitively, qualitatively, or quantitatively measure seven or more drug(s) or substance(s) that are not otherwise specified. This code is utilized in scenarios where a comprehensive analysis of multiple substances is required, allowing healthcare professionals to obtain critical information regarding a patient's exposure to various drugs. The testing methodologies commonly employed for this purpose include gas chromatography, liquid chromatography, and tandem mass spectrometry, either individually or in combination. These advanced techniques enable precise identification and quantification of substances, which is essential for effective patient management and treatment decisions. It is important to note that this code is part of a broader coding system where code 80375 is designated for testing 1-3 drugs or substances, and code 80376 is applicable for 4-6 drugs or compounds. Therefore, CPT® Code 80377 specifically addresses the need for extensive drug screening when multiple substances are suspected or need to be monitored in a patient's sample.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 80377 is indicated for use in situations where there is a need to perform a comprehensive analysis of drug(s) or substance(s) in a patient sample. This may include, but is not limited to, the following conditions:

  • Substance Abuse Evaluation Testing may be warranted for patients suspected of substance abuse to identify the presence of multiple illicit drugs or prescription medications.
  • Medication Monitoring This code is applicable for patients undergoing treatment with multiple medications, where monitoring for compliance or adverse effects is necessary.
  • Legal or Forensic Testing In legal cases, testing for a wide range of substances may be required to provide evidence in court or for employment-related drug screening.

2. Procedure

The procedure associated with CPT® Code 80377 involves several key steps to ensure accurate and reliable results. The following outlines the procedural steps:

  • Sample Collection A biological sample, typically urine, blood, or saliva, is collected from the patient. Proper collection techniques must be followed to avoid contamination and ensure the integrity of the sample.
  • Sample Preparation The collected sample undergoes preparation, which may include processes such as centrifugation or filtration, to isolate the substances of interest for analysis.
  • Analytical Testing The prepared sample is subjected to analytical testing using methodologies such as gas chromatography, liquid chromatography, or tandem mass spectrometry. These techniques allow for the separation and identification of multiple substances present in the sample.
  • Data Interpretation After the testing is completed, the results are analyzed and interpreted by qualified laboratory personnel. This step is crucial for determining the presence and concentration of the identified substances.
  • Reporting Results Finally, a comprehensive report is generated, detailing the findings of the analysis. This report is then provided to the requesting healthcare provider for further evaluation and management of the patient.

3. Post-Procedure

Post-procedure care following the testing associated with CPT® Code 80377 typically involves the interpretation of results by the healthcare provider. The provider will review the findings in conjunction with the patient's clinical history and any relevant symptoms. Depending on the results, further action may be required, such as adjustments to medication, referrals to specialists, or additional testing. It is also important for the provider to discuss the results with the patient, addressing any concerns and outlining the next steps in their care plan. Additionally, documentation of the results and any follow-up actions taken is essential for maintaining accurate medical records and ensuring continuity of care.

Short Descr DRUG/SUBSTANCE NOS 7/MORE
Medium Descr DRUG/SUBSTANCE DEFINITIVE QUAL/QUANT NOS 7/MORE
Long Descr Drug(s) or substance(s), definitive, qualitative or quantitative, not otherwise specified; 7 or more
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Code Not Recognized by OPPS when submitted on Outpatient Hospital Part B Bill Type (12x/13x)
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T2D - Other tests - other
MUE 1
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
2015-01-01 Added Added
Code
Description
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