CPT® Code 81266

Add-On Code

Comparative analysis using Short Tandem Repeat (STR) markers; each additional specimen (eg, additional cord blood donor, additional fetal samples from different cultures, or additional zygosity in multiple birth pregnancies) (List separately in addition to code for primary procedure)

The CPT® Code 81266 pertains to a specific type of molecular genetic testing that utilizes Comparative analysis through Short Tandem Repeat (STR) markers. This procedure is essential for identifying genetic similarities and differences between individuals, particularly in scenarios involving organ or tissue transplants, as well as in prenatal testing. STR markers are sequences of DNA that consist of repeating units of two or more nucleotides, which are typically located in the non-coding regions of genes, known as introns. These markers are crucial for various applications, including documenting engraftment in transplant recipients and detecting any residual disease post-transplant. In the context of prenatal testing, STR markers can be analyzed from fetal cells obtained through procedures such as amniocentesis or chorionic villus sampling. The analysis involves comparing these markers with those from a maternal blood sample to ensure that the fetal cells are not contaminated by maternal cells, which is vital for accurate genetic assessment. The code 81266 is specifically used to report each additional specimen analyzed, such as additional cord blood donors, fetal samples from different cultures, or additional zygosity assessments in cases of multiple births. This allows for comprehensive genetic comparisons and enhances the accuracy of genetic testing outcomes.