CPT® Code 81433

Deleted

Hereditary breast cancer-related disorders (eg, hereditary breast cancer, hereditary ovarian cancer, hereditary endometrial cancer); duplication/deletion analysis panel, must include analyses for BRCA1, BRCA2, MLH1, MSH2, and STK11

The CPT® Code 81433 pertains to molecular genetic testing specifically designed to identify hereditary breast cancer-related disorders. These disorders include hereditary breast cancer, hereditary ovarian cancer, and hereditary endometrial cancer. The procedure involves a duplication/deletion analysis panel that must include analyses for specific genes: BRCA1, BRCA2, MLH1, MSH2, and STK11. This testing is crucial for individuals with a family history of these cancers, as it helps in determining the presence of genetic mutations that may increase the risk of developing these types of cancer. The analysis is performed on genetic material, typically extracted from a specimen of whole blood, and aims to detect variations in the genes that are associated with hereditary cancer syndromes. By identifying these genetic markers, healthcare providers can confirm diagnoses, guide treatment decisions, and assess the risk for family members who may also carry these inherited mutations.