CPT® Code 81455

Solid organ or hematolymphoid neoplasm or disorder, 51 or greater genes, genomic sequence analysis panel, interrogation for sequence variants and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; DNA analysis or combined DNA and RNA analysis

The CPT® Code 81455 pertains to a comprehensive genomic sequence analysis panel specifically designed for the evaluation of solid organ or hematolymphoid neoplasms or disorders. This code encompasses the analysis of 51 or more genes, focusing on the interrogation for sequence variants, copy number variants, rearrangements, or isoform expression, including mRNA expression levels, if performed. The procedure involves advanced molecular genetic testing techniques, such as polymerase chain reaction (PCR) and next-generation sequencing (NGS) or massively parallel sequencing (MPS), which allow for a thorough examination of genetic material. This testing is crucial for patients diagnosed with various types of cancers, including hematolymphoid neoplasms like leukemia and lymphoma, as well as solid organ tumors. By identifying specific genetic markers and alterations within the cancer genome, healthcare providers can better classify the cancer and tailor targeted therapies, ultimately leading to improved patient outcomes. The analysis may require blood or tissue samples, which are obtained through separate reportable procedures, ensuring that the genetic assessment is comprehensive and accurate.