CPT® Code 81510

Fetal congenital abnormalities, biochemical assays of three analytes (AFP, uE3, hCG [any form]), utilizing maternal serum, algorithm reported as a risk score

The CPT® Code 81510 refers to a specific laboratory test that assesses fetal congenital abnormalities through biochemical assays of three analytes found in maternal serum. This test is crucial during pregnancy as it helps in evaluating the risk of certain chromosomal abnormalities in the fetus, including trisomy 18, trisomy 21 (commonly known as Down syndrome), and open neural tube defects such as spina bifida. Additionally, it provides insights into potential pregnancy outcomes, including the risk of failure to carry the pregnancy to term or complications such as preeclampsia and gestational trophoblastic disease. The analytes measured in this test include alpha-fetoprotein (AFP), estriol (uE3), and human chorionic gonadotropin (hCG) in any form. The results of these tests are reported as a risk score, which is generated using an algorithm that interprets the levels of these analytes. For optimal sensitivity, the blood sample for this test should ideally be collected between 14 weeks, 0 days and 24 weeks, 6 days of gestation. The blood sample is obtained through a venipuncture, which is a separate and reportable procedure, and the serum is analyzed using advanced techniques such as quantitative chemiluminescent immunoassay or electroluminescence assay.