CPT® Code 81512

Fetal congenital abnormalities, biochemical assays of five analytes (AFP, uE3, total hCG, hyperglycosylated hCG, DIA) utilizing maternal serum, algorithm reported as a risk score

The CPT® Code 81512 refers to a specific blood test designed to assess maternal serum levels of five key analytes during pregnancy. This test is crucial for evaluating the risk of various fetal congenital abnormalities, including chromosomal conditions such as trisomy 18 and trisomy 21 (commonly known as Down syndrome), as well as open neural tube defects (ONTD) like spina bifida. Additionally, it aids in predicting pregnancy outcomes, including the likelihood of preterm birth or complications such as preeclampsia and gestational trophoblastic disease. The five analytes measured in this test are alpha-fetoprotein (AFP), estriol (uE3), total human chorionic gonadotropin (hCG), hyperglycosylated human chorionic gonadotropin (hCG-H), and Inhibin A Dimer (DIA). The test is most effective when the maternal blood sample is collected between 14 weeks and 24 weeks, 6 days of gestation. The blood sample is obtained through a venipuncture procedure, and the serum is analyzed using advanced quantitative chemiluminescent immunoassay or electroluminescence assay techniques. The results of this test are reported as a risk score, which provides valuable information for healthcare providers in managing prenatal care and counseling expectant mothers.