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Official Description

Acetaldehyde, blood

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82000 refers to a laboratory test specifically designed to measure the levels of acetaldehyde in the blood. Acetaldehyde is an organic chemical compound that occurs naturally in various foods such as coffee, bread, and ripe fruits. It can also be intentionally added to food products as a flavoring agent or preservative, and is utilized as a solvent in various manufacturing processes. In the human body, acetaldehyde is primarily produced as a byproduct of alcohol (ethanol) metabolism. When alcohol is consumed, the enzyme alcohol dehydrogenase facilitates the conversion of ethanol into acetaldehyde within the liver. Subsequently, acetaldehyde is metabolized by the enzyme acetaldehyde dehydrogenase, along with cysteine-containing glutathione, to produce acetate. This acetate is then further broken down into water and carbon dioxide, which are eliminated from the body through urine and respiration. Monitoring acetaldehyde levels is crucial due to its potential adverse effects, which may include cardiovascular issues such as atherosclerosis, ischemia, heart failure, hematologic coagulation disorders, and hepatic injury or failure. The test requires a blood sample, which is obtained through a separately reportable venipuncture, and the analysis is conducted using headspace gas chromatography to ensure accurate measurement of acetaldehyde concentrations in the bloodstream.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The acetaldehyde blood test (CPT® Code 82000) is indicated for monitoring exposure to acetaldehyde, particularly in individuals who may be at risk due to various factors. The following conditions and situations warrant the performance of this test:

  • Monitoring Alcohol Metabolism: Individuals who consume alcohol may require testing to assess the levels of acetaldehyde produced during the metabolism of ethanol.
  • Assessment of Toxic Exposure: Patients who have been exposed to environments or substances containing acetaldehyde, such as certain industrial settings, may need evaluation for potential toxicity.
  • Evaluation of Cardiovascular Health: Individuals presenting with symptoms related to cardiovascular conditions, such as atherosclerosis or ischemia, may be tested to determine if acetaldehyde levels are contributing factors.
  • Investigation of Hepatic Injury: Patients with signs of liver dysfunction or injury may undergo this test to evaluate the role of acetaldehyde in their condition.

2. Procedure

The procedure for conducting the acetaldehyde blood test involves several key steps to ensure accurate results. The following outlines the procedural steps:

  • Step 1: Patient Preparation Before the test, the patient may be advised to refrain from alcohol consumption and certain foods that could interfere with the results. Proper preparation is essential for obtaining accurate measurements of acetaldehyde levels.
  • Step 2: Venipuncture A qualified healthcare professional performs a venipuncture to obtain a blood sample. This step is crucial as the blood sample must be collected in a manner that prevents contamination and ensures the integrity of the sample for testing.
  • Step 3: Sample Handling After collection, the blood sample is handled according to laboratory protocols to preserve its quality. This may involve specific storage conditions and timely processing to prevent degradation of acetaldehyde.
  • Step 4: Laboratory Analysis The blood sample is analyzed using headspace gas chromatography, a technique that allows for the precise measurement of acetaldehyde levels in the blood. This method is chosen for its sensitivity and accuracy in detecting volatile compounds.

3. Post-Procedure

Post-procedure care for the acetaldehyde blood test is generally minimal. Patients may be advised to resume normal activities immediately after the venipuncture, as there are typically no significant side effects associated with the blood draw. However, it is important for patients to monitor the venipuncture site for any signs of excessive bleeding, swelling, or infection. Results from the acetaldehyde test will be interpreted by the healthcare provider, who will discuss the findings and any necessary follow-up actions based on the patient's clinical context and history.

Short Descr ASSAY OF BLOOD ACETALDEHYDE
Medium Descr ASSAY ACETALDEHYDE BLOOD
Long Descr Acetaldehyde, blood
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2015-01-01 Deleted Code deleted
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
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