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CPT®
82013

CPT® Code 82013

Official Description

Acetylcholinesterase

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82013 refers to the measurement of acetylcholinesterase levels through a blood test. Acetylcholinesterase is a crucial enzyme predominantly found in red blood cells, playing a significant role in the breakdown of acetylcholine, a neurotransmitter essential for muscle function and various neurological processes. This test is particularly important as elevated levels of acetylcholinesterase can indicate exposure to organophosphate pesticides, which are commonly used in agricultural practices and can have toxic effects on the human body. The test may be utilized for routine screening purposes or specifically when there is a suspicion of exposure based on the presence of certain signs or symptoms indicative of toxicity. Additionally, monitoring acetylcholinesterase levels can be vital in assessing the effectiveness of treatment interventions or determining if treatment has failed. The procedure involves obtaining a blood sample, which is typically collected through a venipuncture, a method that is separately reportable. Following collection, the whole blood sample undergoes testing via photometric analysis, a technique that measures the concentration of the enzyme in the blood, providing critical information for diagnosis and management of potential poisoning or other related conditions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The acetylcholinesterase test (CPT® Code 82013) is indicated for several specific scenarios, particularly related to potential exposure to harmful substances. The following conditions warrant the performance of this test:

  • Routine Screening This test may be performed as part of routine health assessments to monitor acetylcholinesterase levels in individuals who may be at risk of exposure to organophosphate pesticides.
  • Suspected Exposure The test is indicated when there is a suspicion of exposure to organophosphate pesticides, especially in individuals presenting with symptoms consistent with toxicity, such as neurological disturbances or respiratory issues.
  • Monitoring Treatment Acetylcholinesterase levels may be monitored over time to evaluate the effectiveness of treatment interventions in individuals who have been exposed to organophosphate compounds or to assess the need for further medical intervention.

2. Procedure

The procedure for measuring acetylcholinesterase levels involves several key steps that ensure accurate results. The following outlines the procedural steps:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to avoid certain medications or substances that could interfere with the test results. It is essential to gather a thorough medical history to assess any potential risks associated with the test.
  • Step 2: Venipuncture A qualified healthcare professional performs a venipuncture to obtain a blood sample. This involves inserting a needle into a vein, typically in the arm, to draw a sufficient volume of blood for testing. The site is cleaned with an antiseptic to minimize the risk of infection.
  • Step 3: Sample Handling Once the blood sample is collected, it is carefully handled and transported to the laboratory for analysis. Proper labeling and documentation are crucial to ensure the sample is correctly identified and processed.
  • Step 4: Photometric Analysis In the laboratory, the whole blood sample undergoes photometric analysis. This technique measures the concentration of acetylcholinesterase in the blood by assessing the light absorbance of the sample, providing quantitative results that reflect the enzyme's levels.

3. Post-Procedure

After the acetylcholinesterase test is completed, the patient may be monitored briefly to ensure there are no immediate adverse reactions to the venipuncture. Typically, there are no specific post-procedure care requirements, and patients can resume their normal activities unless otherwise advised by their healthcare provider. The results of the test will be analyzed and reported, and follow-up consultations may be scheduled to discuss the findings and any necessary further actions based on the acetylcholinesterase levels measured.
Short Descr ACETYLCHOLINESTERASE ASSAY
Medium Descr ASSAY OF ACETYLCHOLINESTERASE
Long Descr Acetylcholinesterase
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
2011-01-01 Changed Guideline information changed.
Pre-1990 Added Code added.
Code
Description
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