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Adenosine, 5-monophosphate, cyclic (cyclic AMP) is a critical nucleotide involved in various cellular processes, particularly in intracellular signaling. This compound is derived from adenosine and is found in RNA as an ester of phosphoric acid. The measurement of cyclic AMP levels in blood or urine is essential for diagnosing certain medical conditions. The enzyme adenylate cyclase synthesizes cyclic AMP from ATP, and its production is regulated by hormones such as adrenaline and glucagon. The testing for cyclic AMP is primarily utilized in the differential diagnosis of hypercalcemia, a condition characterized by elevated calcium levels in the blood, and it may also serve as an adjunctive test for assessing parathyroid hormone resistance. To perform this test, a blood sample is collected through venipuncture, which is a separately reportable procedure. The collected plasma is then frozen and analyzed using radioimmunoassay techniques. Additionally, urine samples can be collected either as a 24-hour specimen preserved with 10 ml of 6M hydrochloric acid or as an unpreserved random sample, with a minimum volume of 5 ml. It is important to document the total volume of urine voided and the time interval for accurate testing. The urine may also be analyzed using radioimmunoassay or high-pressure liquid chromatography methods.
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The measurement of Adenosine, 5-monophosphate, cyclic (cyclic AMP) levels is indicated for specific clinical scenarios, particularly in the evaluation of certain metabolic and endocrine disorders.
The procedure for measuring cyclic AMP levels involves several key steps to ensure accurate results.
After the procedure, it is important to ensure that the blood and urine samples are properly labeled and stored to maintain their viability for testing. The results of the cyclic AMP tests will be interpreted in conjunction with clinical findings and other laboratory results to provide a comprehensive assessment of the patient's condition. Follow-up may be necessary based on the test outcomes, and healthcare providers should communicate any relevant findings to the patient for further management.
| Short Descr | ASSAY OF ADP & AMP | Medium Descr | ADENOSINE 5-MONOPHOSPHATE CYCLIC | Long Descr | Adenosine, 5-monophosphate, cyclic (cyclic AMP) | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. |
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| Pre-1990 | Added | Code added. |
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